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We’ve researched and tested dozens of probiotics for women’s gut health —these are our top picks for their natural, high quality ingredients and potent AFUs/CFUs.

Looking to support your gut health? Us too. Gut health is essential to wellness and feeling good in our bodies, as “our microbiome…helps to shape our immune system,” according to transplant gastroenterologist Dr. Shilpa Ravella. Since a large portion of our immune system lives in the gut, it’s important to nourish our gut microbiota through promoting antibodies production, and reducing inflammation—all of which probiotics do! Probiotics support our gut health in more ways than one. From balancing bacteria in the gut, to improving digestive health, managing IBS, and even mood and cognitive function, a high quality probiotic goes a long way.  

Seed vs. AG1 vs. Ritual – What makes a good probiotic?

With all the information out there on the types and strains of probiotics that help support our gut needs, it can be confusing to know where to start. That’s why when choosing the best probiotic for gut health, it’s important to consider the following:

-Strain Type & Diversity: A good probiotic should specify which strains are in their product, as some strains can support certain health needs better or have unique properties and benefits. Generally, a probiotic with a highly diverse strain composition is more beneficial to gut heath.

Shelf Stability & Survivability: Since probiotics are living organisms, they won’t be of much help if they are not active. A good probiotic will list whether it’s shelf-stable or requires refrigeration (both options are good!), and its guaranteed potency through its expiry date. Also ensuring the probiotic you choose offers a timed release or enteric-coating is beneficial, as these both protect probiotics from harsh stomach acids, which can reduce their effectiveness before they reach your intestines.  

Synbiotic Formula: While most probiotics don’t contain pre- or post- biotics, formulas that do will help probiotics thrive, grow and remain active. (We’ve included ones that do in this list!) With synbiotic formulas, you’ll achieve better and more well-rounded support that assists in feeding the healthy bacteria in the gut and maintaining the integrity of the gut barrier. 

AFU: While CFU is common in assessing how many living and reproducing microorganisms are in a probiotic supplement, AFU offers a more functional and accurate representation of microorganism count. AFU assesses how many living and metabolically active cells exist using a fluorescent dye test, whereas CFU involves counting colonies through a culture sample (which thrives only in certain conditions). Through this assessment, AFU measurements provide valuable insight into the viability and ability of microorganisms to survive under different conditions, which is a crucial factor in the effectiveness of a good probiotic. It’s important to note that neither one is necessarily better than the other, simply AFU provides a much more accurate snapshot of microorganism count than CFU. 

Now, when it comes to effective probiotic options, Seed, AG1, and Ritual are popular choices on the market, but how do they compare?  When it comes to strain type and diversity, Seed takes the lead with 24 probiotic strains that support digestive, skin, and cardiovascular health. Both Seed and Ritual are shelf-stable and offer delayed release, and all three formulas offer synbiotic properties. When it comes to AFU/CFU count, Seed has 53.6 billion AFU, Ritual has 11 billion CFU, and AG1 has 7.2 billion CFU.

Ritual is a great choice if your looking for daily gut support, while Seed is an option to turn to if you require a higher level of digestive and whole body support. We recommend AG1 if you’re always on the go and have a harder time meeting your nutrition goals as it contains over 75 ingredients to help support whole body health, in addition to probiotics. When comparing these three products, there are areas where one thrives over another–however we agree that each of these brands offers high quality formulas that will benefit your gut health needs. 

In this guide, we’ve covered the ins and outs of what these popular probiotics offer, as well as a few more of our favorite brands, so you can make the most informed decision for your health. 

Our criteria:

  • NATURAL, HIGH QUALITY INGREDIENTS | Each of these probiotics is made from ingredients that are naturally sourced, tested, and proven effective. No fillers, gums, or binders here! 
  • AFFORDABILITY | We’ve offered a variety of options at various price points, while prioritizing more affordable choices for better accessibility. 
  • ACTIVE FLUORESCENT UNITS (AFU) | We’ve done the work for you by including the best brands that provide detailed CFU count (and AFU where available).

The below brands are the best of the best when it comes to science-backed and clinically proven pre-, pro- and postbiotics. From third-party testing to sustainable production to superb ingredients that ensure our guts are healthy and happy, these gut health supplements keep everything regular and flowing. 😉

If you’re look to up your supplement routine to more natural products with organic ingredients, we’ve got you covered with our guides on best magnesium supplements, fiber supplements, and women’s multivitamins to help keep your health in tip-top shape. 

**This review is not health advice. Please talk to your OBGYN or healthcare provider before adding any supplements to your diet.

Best Overall | Best Powdered Probiotic | Most Affordable

1. Seed

Recycled materials
Woman owned

Clean Ingredients | Vegan; free from gluten, dairy, soy, nut, shellfish, corn, & sesame; glyphosate/AMPA-free, no binders or preservatives; prop-65 compliant
AFU (Active Fluorescent Units) | 53.6 billion
Price | $50/month

Seed‘s clinically-researched daily synbiotic (probiotic + prebiotic) is formulated with strains to support digestive health, gut barrier integrity, gut immune function, and even cardiovascular and dermatological health. The brand has set the bar incredibly high with production standards, testing, biofermentation, and survivability—Seed’s ViaCap technology ensures the probiotic makes it to your colon while still alive. This is the best of the best when it comes to caring for your gut health and microbiome. Even better, the brand has impressive sustainability initiatives and subscription options (monthly refills come in biofilm sachets!) so you never miss your daily dose.

Seed Review | “I have to tell you, this is the first probiotic I have ever taken that actually does something for me. From early on I have noticed a difference in my elimination and I have always had an ongoing problem, never regular. So this is very exciting for me to have a product that actually works!” – Anonymous

2. Ritual

B corp
Recycled materials
Woman owned

Clean Ingredients | Vegan; gluten-free & allergen-friendly; non-GMO; third-party tested
CFU (Colony Forming Units) | 11 billion
Price | $54/month

Ritual‘s Synbiotic+ is a 3-in-1 clinically-studied prebiotics, probiotics, and postbiotics formula to support a balanced gut microbiome. It includes 11b CFUs for digestive support, plus two of the world’s most clinically studied probiotic strains. We love that Ritual uses Made Traceable® ingredients and that you only have to take one capsule—which is formulated as a delayed-release capsule so it reaches your colon while still alive. Take one a day to support your gut health, gut barrier, and immune system. 

Ritual Review | “This product has completely changed my gut health. From suffering for nearly 4 years with bad digestive issues, this was my last ditch effort before doing exploratory scans and colonoscopies. Decided to begin this product in October and had a colonoscopy scheduled for January. Ended up canceling the colonoscopy because this product cured all my issues. I haven’t had but maybe two or three “flare ups” (diarrhea) in almost 4 months. I am a true believer of this product and will continue to put forth the money to be better...This was a life changing product and I am so happy to have found a product that is non invasive and actually WORKS!” – DP [See all reviews

3. AG1

Climate neutral
Recycled materials

Clean Ingredients | Vegan; organic ingredients; non-GMO; free of fillers & preservatives; free from gluten, corn, eggs, peanuts, dairy, & animal by-products
CFU (Colony Forming Units) | 7.2 billion
Price | $99/month; discounted subscriptions available (20%+ off)

Our editors are big fans of AG1 (formerly Athletic Greens) for daily greens, vitamins and nutrients, and—yes—pre- and probiotics. (Read our review here!) One yummy scoop of this green powder (mix with water or add to your morning smoothie) includes 75 superpower ingredients for gut and whole body health—including nutrient-dense extracts, herbs, and antioxidants, digestive enzymes, phytonutrients, multiminerals, and so much more. We love that AG1 can be enjoyed as a morning beverage, especially if you have difficulty swallowing pills. The travel packs are an easy option to take on the go so we never miss our daily serving.

AG1 Review | “For years it bothered me that I couldn’t get enough of the foods I needed to give me the health my body deserved, and now with a toddler, it was even harder. Until I was introduced to AG1. I was amazed how easily it fit into my routine, drinking this delicious combination before my daughter wakes up, and getting on with my day .” Tina M., Professional long distance runner [See all reviews]

4. Perelel

American made
Budget friendly
Recycled materials
Woman owned

Clean Ingredients | Gluten-free, soy-free, dairy-free; non-GMO; third-party tested
CFU (Colony Forming Units) | 10 billion
Price | $28/month; discounted subscriptions available (10% off)

Perelel is the brand we love for our conception journey, whether we’re trying to get pregnant, currently growing a baby, or recovering from postpartum. Founded specifically by an OBGYN, the brand has a line of prenatal vitamins with bioavailable ingredients specific to each trimester (including a men’s multi-pack), as well as a daily probiotic for maximum gut support. Thanks to a Carbonfree partnership, Perelel supports carbon offset projects and uses eco-friendly packaging for its supplements, which is better for you and the planet.

Perelel Review | “Probiotics can help support optimal gut microbiome health at all stages of life—from preconception to postpartum gut health is critically important. I especially love Perelel’s Daily Probiotic because it was formulated with specific strains for women and pregnancy.” – Dr. Caitlin O., ND & Midwife [See all reviews]

5. Needed.

1% for the planet
American made
B corp
Climate neutral
Woman owned

Clean Ingredients | Non-GMO; allergen friendly; third-party tested
CFU (Colony Forming Units) | 30 billion
Price | $60/month; discounted subscriptions available (10%+ off)

Needed. is another one of our editor-tested and approved brands for daily vitamins, including prenatals and probiotics that provide microbiome support for you and your baby. Formulated in partnership with leading perinatal and microbiome experts, this pre- and probiotic includes clinically studied spore-forming and non-spore-forming strains and supports key perinatal needs like vaginal balance, digestive comfort, and iron absorption. We love the subscription options and the various plans to save on monthly supplies of supplements for both partners.

Needed. Review | “This pre/probiotic has helped so much! My baby started getting colicky and had issues with constipation being breastfed. Her symptoms have resolved, and she’s back on a schedule for regular bowel movements now. I will definitely not let this run out before reordering!” – Atlanta H. [See all reviews]

6. Ora

American made
Plant trees

Clean Ingredients | Dairy-free, gluten-free, soy-free; non-GMO; organic; vegan
CFU (Colony Forming Units) | 20 billion
Price | $41/month; discounted subscriptions available (20% off)

If you’re in search of a powdered probiotic, you’re in luck—Ora’s Trust Your Gut shelf-stable vegan probiotic power is a synbiotic powerhouse. With 7 highly-researched probiotic strains alongside natural prebiotic fiber from organic apples and Jerusalem artichokes, this probiotic will help you regulate your digestive system and improve bloating in a matter of days. Be sure to start slow (half a scoop for the first week or two), to minimize any sensitivity as your gut adjusts to the new strains. If you are taking or recently took antibiotics, Ora is also a great choice to replenish your gut microbiome. Mix it with your smoothie, water or sprinkle it on your food–the options are endless! 

Ora Review | “What a great product. Finally, probiotics where I don’t have to swallow capsules. Very pure, tastes great, and is a supper support for gut health. Bravo Ora! Another great product.” – Pamela G. [See all reviews]

7. Garden of Life

American made
B corp
Cruelty free

Clean Ingredients | No binders, fillers or carriers; whole food vitamins; non-GMO; dairy-free & soy-free options available
CFU (Colony Forming Units) | 50–85 billion
Price | $34–$48/month; discounted subscriptions available (15%+ off & free shipping)

There’s a probiotic for everybody with Garden of Life’s extensive collection. Whether you’re looking for UTI support, a daily synbiotic formula, or one for ages 50+, Garden of Life’s probiotics provide nourishing care for both your gut and whole body health. With options boasting an impressive 50–85 billion CFU with some products including up to 33 strains, this potent formula is made to cover all the bases and offer high-level digestive fuel. We love that these formulas include whole food vitamins, minerals, and prebiotics to benefit overall colon and immune health. (Some are also Dr. formulated!) What more could you ask for?

Garden of Life Review | “I love that GOL has products for women over 50, and these have been a great addition to my health regimine! After dealing with some GI issues early this year, my doctor suggested adding a probiotic to my daily supplements. I really believe these have helped to heal my gut and provide some things I was missing. Thank you GOL for your superb products and reasonable prices!” -Tammy G [See all reviews]

8. Thorne

American made
Budget friendly

Clean Ingredients | Gluten-free, dairy-free, soy-free
CFU (Colony Forming Units) | 10 billion
Price | $35/month; discounted subscriptions available (20% off)

For vaginal and urinary tract needs, consider Thorne’s daily probiotic, made with clinically-studied strains and 10 billion cultures. This minimal formula is designed to target those who experience vaginal and urinary issues. This includes unwanted yeast growth, UTIs, and other vaginal bacterial imbalances. With daily use, this supplement promotes healthy microflora populations in the gut and balanced vaginal pH levels. No more itching and discomfort here! Thorne supplements are manufactured in the USA and according to third-parties is the ‘#1 most highly recommended brand by Healthcare practitioners’.  

Thorne Review | “I have been taking this for about three months. Prior to taking this, I was having almost monthly yeast infections. Since taking this, I have had none. Love this product!” – Natasha P. [See all reviews]

9. MaryRuth Organics

B corp
Budget friendly
Woman owned

Clean Ingredients | Vegan; dairy-free, gluten-free, nut-free, soy-free; organic; non-GMO
CFU (Colony Forming Units) | 5–63 billion
Price | $30–$45/month; discounted subscriptions available (10% off)

Prebiotics, probiotics, and postbiotics unite in MaryRuth Organics high quality daily supplements. Each probiotic product goes to work on different needs, with the overall goal of helping boost our digestive health. If capsules are tough to swallow, MaryRuth offers probiotics in powder, liquid and even gummies form, which is perfect for getting your daily dose in your preferred method! You’ll also find options for postnatal care, hair, skin and nail health, and even added turmeric for its anti-inflammatory properties. No matter what option you go for, every product is vegan with many USDA organic options. It’s no wonder MaryRuth’s has over 12,000 5-star reviews!

MaryRuth Organics Review | “I was looking for something that was a probiotic, but also helped me with vaginal health and gut health and so far this has been great! I will keep buying.” – Abigail B. [See all reviews