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We’ve reviewed the best clean supplements on the market — these are our picks for relief from PCOS with natural ingredients and gentle formulations.

For too long menstruation has been discussed in hushed voices, in private settings. Perhaps this silence is why, even though Polycystic Ovary Syndrome (PCOS) affects an estimated 8–13% of reproductive-aged people, up to 70% of affected folks are undiagnosed. PCOS can cause irregular menstrual cycles, infertility, and imbalanced hormones, particularly estrogen and progesterone. All this plus mood changes, weight fluctuation, and bloating. Simply put: PCOS can make you feel like you’re not yourself — not only during your cycle. While there’s no cure, supplements can make a vast difference to your quality of life, overall health, and mood.

What should you look for in a PCOS supplement?

Hormones are volatile, and any health product for your cycle is extremely personal. That’s why sticking to natural products with gentle formulations is a good approach for PCOS supplements. Anything laden with synthetic ingredients and other hormones can further disrupt your body’s systems. All the supplements on this list aim to mimic your body’s natural ratios of nutrients to support your health without interfering with your natural rhythms.

A mix of the following compounds is usually found in PCOS supplements. Here’s what to look for, and what each element offers:

  • Inositol helps regulate insulin sensitivity and balance hormone levels.
  • Vitamin D plays a crucial role in hormone production and regulation.
  • Myo-inositol and d-chiro-inositol can help regulate menstrual cycles and improve fertility. Look for a 40:1 ratio, which is your body’s natural ratio.
  • Antioxidants like N-acetylcysteine (NAC) and coenzyme Q10 (CoQ10) help reduce inflammation and support ovarian function.
  • Magnesium can regulate glucose, insulin, and blood pressure. Plus, folks with PCOS are 19 times more likely to be deficient in magnesium — so a magnesium supplement might be a good idea.
  • Zinc for pain reduction during menstruation, plus insulin resistance and lipid balance.

One thing to note: PCOS supplements aren’t like bloating pills — they often don’t work overnight. Many take a few weeks to months to get you back to feeling your best. Before making this type of medical commitment, we encourage you to speak with your doctor to determine if PCOS supplements are a fit. Take extra caution if you have any other preexisting conditions or take other medications.

Our methodology & criteria:

We’ve personally taken and researched the top clean supplement brands — these are our favorites offering PCOS relief. We’ve selected brands that are made with natural ingredients and are easy and gentle to take. This piece is regularly updated with options that meet our standards.

  • NATURAL INGREDIENTS | The brands below use natural ingredients to balance hormones without causing further disruption.
  • GENTLE FORMULATIONS | These science-backed formulas are multipurpose nutrition powerhouses that provide holistic health benefits in a daily serving.

Looking for other ways to support your nutrition and address common nutrition deficiencies? Check out our guides to the best fiber and magnesium supplements, too.

1. Thorne (Hormone Advantage, Ovarian Care)

American made
Cruelty free
Natural materials
Science backed
Subscriptions available

Best For | Hormone balancing
Active Ingredients | Hormone Advantage: Broccoli, DIM, Pomegranate; Ovarian Care: Inositol, Green Tea Extract, Wild Blueberry Complex, Coenzyme Q10, Folate, Pomegranate
Price Starting At | $47/60 capsules

Thorne has two impressive offerings for PCOS: Hormone Advantage and Ovarian Care. Both support healthy estrogen production to mitigate hormone imbalances and ease PCOS symptoms. Their effects aren’t just helpful once a month, they promote long-term hormonal balance throughout all the weeks of the year. Using natural ingredients like Pomegranate, an antioxidant, both supplements help the body metabolize and detoxify excess estrogen to promote balanced hormones and enhanced ovarian function. We love the support these supplements offer for physical and mental well-being.

Customer review | “So helpful: This has eased the severity of my monthly cycles. Stabilized moods swings, tolerable cramps, etc. What a relief!” – Emily W. (Read more reviews.)

2. Peach Perfect

Natural materials
Science backed
Subscriptions available

Best For | Active lifestyles
Active Ingredients | Myo-inositol and D-chiro inositol, omega-3, magnesium, vitamin D3, and zinc. 
Price Starting At | $30/120 capsules

The research-backed PCOS supplement from Peach Perfect supports your holistic health to keep you at your strongest at all times using powerful nutrition. This 3-in-1 multivitamin, called Happy Hormones, contains a clinical 40:1 blend of myo-inositol and D-chiro inositol, omega-3, magnesium, vitamin D3, and zinc. This combination promotes period regulation and reduces androgen levels, addressing symptoms such as irregular periods and weight fluctuation. Happy Hormones’s blend of vitamins and minerals support inflammation relief, mood regulation, and insulin balance. Take four pills daily and see the benefits in a matter of weeks.

Customer review | “It absolutely does what it says” – Shonta Jones (Read more reviews.)

3. Mela

Natural materials
Science backed
Subscriptions available
Woman owned

Best For | People of color
Active Ingredients | Vitamins A, C, D3, E, B6, B12; Magnesium, Zinc, Biotin, Lions Mane, Probiotic blend, Myo-inositol, D-chiro-inositol
Price Starting At | $40/60 capsules

Mela’s unique philosophy puts BIPOC wellness-seekers at the forefront. Did you know that melanin actually impacts how our bodies produce certain nutrients? Pair that with a medical field that underserves people of color, and you can easily see why Mela’s mission is so important. To fill these gaps, Mela created the Daily Essential, a multivitamin and probiotic that even contains adaptogens, to support holistic wellness. The founder was inspired by her own journey with PCOS, so it’s hormone balancing too.

Customer review | “I’m on week two and I can already tell a difference in my energy! I can finally throw away all the bottles of vitamins ( that only address one thing) and replace with MELA. This one vitamin has everything I need in one !! Most importantly no headaches from these vitamins!!!” – Jennifer J. (Read more reviews.)

4. Natalist

American made
Gluten free
Science backed
Subscriptions available

Best For | Pre-natal support
Active Ingredients | Inositol
Price Starting At |$35/120 capsules

Inositol is the power player in Natalist’s Inositol Plus. As a fertility brand, Natalist offers a comprehensive approach to fertility that centers around reproductive health — especially for folks with PCOS. Backed by science and rigorously tested, they center folks with PCOS to help them navigate potential fertility challenges. This supplement mimics the body’s natural 40:1 ratio of Myo-Inositol (MI) and D-Chiro Inositol (DCI) to improve egg quality, regulate menstrual cycles, and enhance fertility opportunities. If PCOS is interfering with your baby plans, this could be the supplement for you.
Customer review | “Great Product!Loved It! Eased PMS symptoms; this month was a breeze.” – Michaela C (Read more reviews.)

5. S’moo

Dairy free
Gluten free
Natural materials
Science backed
Subscriptions available

Best For | Improved energy
Active Ingredients | Myo-Inositol, Magnesium, N-acetyl Cysteine, Vitamin D3, Ashwagandha, Chromium, Zinc, Coconut Oil Powder
Price Starting At | $55/30 servings

Available in capsules or a powder, S’moo’s Ovary Good supplement is a hormone-balancing formula specifically targeted at treating PCOS symptoms. It’s formulated from natural vitamins, minerals, and herbs combined with myo-inositol and d-chiro-inositol for a comprehensive symptom reliever. It balances hormones, regulates your menstrual cycle, and helps improve energy and manage stress, too. Inspired by her journey with PCOS, S’moo’s founder wanted to offer a natural solution to a whole host of PCOS symptoms, without having to take so many pills. One scoop of S’moo can be easily added to your morning smoothie. Ah, now we understand the name!

Customer review | “I was skeptical at first because I didn’t think it would work. From day 1 I was hooked. My energy levels are up. My face is clearing up. I just feel good even when I don’t. If that even makes sense! Wonderful experience. Totally recommend after years of dealing with PCOS Symptoms.” – Lucy P. (Read more reviews.)

Featured image is from Mela