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We’ve reviewed the best clean supplements on the market — these are our favorites for staying young at heart, and in your body and mind, too.

Aging is a beautiful thing. Most older folks are more sure of themselves, confident, and at peace than they were during their youth. Sometimes this comes with one caveat: “I wish I had the energy of a 20-something.” Even if you’re aging with grace, you might still be looking to age with vitality and vibrancy, too. Whether you want to beat the daily fatigue that starts to set in as your cells start breaking down, set yourself up to run after grandchildren, or have adventures well into your life, the best time to optimize your health for the long haul is today. Longevity supplements can offer some support to our bodies and minds as we change over the years.

What should you look for in a longevity supplement?

Does seeking out longevity necessarily mean adding a spoonful of fish oil to your morning? While fish oil is a super supportive ingredient for aging well, longevity supplements today are available in many easy-to-take varieties with formulas that combine ingredients while avoiding side effects. This list is built around pills and chewables that contain some of the most important longevity-sustaining components — take a look at the list below to learn more.

  • Omega-3 fatty acids: Powerhouse nutrients that support heart health, brain function, and overall longevity. Look for supplements rich in EPA and DHA, the two most beneficial forms of omega-3. These fatty acids help reduce inflammation for cases of rheumatoid arthritis, lower blood pressure, and support cognitive function as we age.
  • Collagen: You’ve seen it in skincare products, but this protein is great for overall health. It’s responsible for keeping our skin firm, our hair glossy, and our joints flexible. As we age, our natural collagen production starts to decline, so supplements offer a much-needed boost. Opt for hydrolyzed collagen supplements, which are more easily absorbed by the body.
  • C15:0 (pentadecanoic acid): The first essential fatty acid discovered since omega-3, this superstar ingredient strengthens cells against age-related breakdown, repairs mitochondrial function for added energy, and naturally activates receptors that regulate metabolism, immunity, mood, sleep, and appetite, supporting overall health as we age.
  • Coenzyme Q10 (CoQ10): Another popular skincare ingredient, Coenzyme Q10, or CoQ10, is a powerful antioxidant that supports energy production and cellular health for heart health, muscle function, and overall vitality. As we age, our natural levels of CoQ10 decline, so look for supplements containing ubiquinol, the active form of CoQ10, for optimal absorption and effectiveness.

As always, be sure to consult a doctor before starting a new supplement regimen. They can help isolate what supplements you need most, and what combinations to seek out or avoid.

Our criteria:

We’ve personally taken and researched the top clean supplement brands — these are our favorite longevity supplements offering support as we age. We’ve selected brands that make use of high-quality and effective natural ingredients, and are easy and gentle to take. This piece is regularly updated with new options that meet our criteria below.

  • EASY TO TAKE | We’ve chosen brands that allow you to get all the nutrients you need in just a few capsules or chewables daily, with minimal side effects or unpleasant tastes.
  • NATURAL INGREDIENTS | The supplements on this list do not contain artificial colors, flavors, or unnecessary preservatives, fillers, or additives. We’ve highlighted which brands are vegan, vegetarian, gluten-free, soy-free, dairy-free, GMO-free, and so on so you can make the best choice for your lifestyle and needs.
  • GENTLE FORMULATIONS | We’ve chosen supplements with high-quality, bioavailable ingredients that are easily absorbed by the body. The dosage and combination of elements has been carefully considered by each brand.

Interested in exploring other helpful supplements? Check out our favorites for fiber and magnesium.


1. Timeline

Dairy free
Gluten free
Science backed
Subscriptions available

Best For | Muscle performance and recovery
Active Ingredients | Urolithin A (500mg of Mitopure)
Price Starting At | $125/60 capsules

Timeline’s Mitopure is the first and only clinically tested, highly pure Urolithin A postbiotic. What does this mean? While some natural antioxidants like pomegranate juice contain this nutrient, you’re unlikely to drink enough to have the desired anti-aging effects. However, Mitopure delivers the right amount of Urolithin A to supercharge your cellular health — which is about 6 glasses of pomegranate juice. Urolithin A is found in the gut and has immediate benefits like anti-inflammation, increased energy, and neuroprotection. Its long-term benefits include cellular rejuvenation to improve cell health, recovery, and muscle performance. 

Customer review | “I feel like I have gotten younger: I simply feel like I have more energy to do everything. This is like a caffeine jolt without any of the side effects. I am hoping these results continue and build on what is currently happening? I’m willing to continue for a couple of months to find out.” – Kathryn C (Read more reviews.)


2. Fatty15

Gluten free
Science backed
Subscriptions available
Vegan

Best For | Balanced metabolism
Active Ingredients | C15:0
Price Starting At | $50/30 capsules

Cellular breakdown might be inevitable as we age, but did you know that you can slow it down? With the help of C15:0, the first essential fatty acid to be discovered in 90 years  (by improving the health of older dolphins, no less!), fatty15 helps make your cells stronger and more stable. By building up your cell resilience, C15:0 reduces the risk of cell damage to help you be active in the cell-preservation process at any age. Plus, it helps support healthy metabolism, balanced immunity, and heart health. Depending on your needs, it can be a great alternative to omega-3 and provide a more balanced overall picture of health. If you’re into leveraging emerging science and tech for your health, fatty15 is the choice for you.

Customer review | “I look 5 years younger and feel it too!: My blood work and skin! My Triglycerides went from 204 to 133, (have been dieting and walking 7 miles a day) cholesterol is all in normal range too. My crows feet are nearly gone and fine lines on my face, neck and chest are hard to find! I look 5 years younger and feel it too!” – Angie W. (Read more reviews.)

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3. NOVOS

Gluten free
Science backed
Subscriptions available
Third party tested
Vegan

Best For | Optimized organ function
Active Ingredients | Trehalose, Acetic acid via Apple Cider Vinegar (ACV), Nattokinase, Rutin, Lutein, Zeaxanthin, Inulin
Price Starting At | $69/120 chewables

Organ function is vital to comfortable, healthy living. These chewable supplements from NOVOS make it easy to maintain overall organ function from cognitive and cardiovascular health to balancing metabolism, strengthening muscles, maintaining gut health, and supporting eye wellness. By fighting inflammation, oxidative stress, and other stressors, they support immediate energy and DNA repair to nourish your body holistically. Support your vital organs such as the brain, eyes, heart, liver, kidneys, muscles, and gut with the unique blend of nutrients in NOVOS.

Customer review | “Perfect addition to my wellness routine: I have a major sweet tooth and these chews serve as the perfect treat post-meals. It’s a one-two punch that I’m also supporting my organ health and looking after my overall wellbeing” – Hannah G (Read more reviews.)


4. Tally Health

Science backed
Subscriptions available

Best For | Personalized support
Active Ingredients | Calcium Alpha-Ketoglutarate, Quercetin, Trans-resveratrol, Fisetin, Spermidine
Price Starting At | $79/month

Tally takes a holistic approach to aging and vitality, starting with an epigenetic test to help you set personalized age goals and provide a comprehensive analysis of how your cells are aging. From there, they work with you to set wellness goals and recommendations that go beyond their supplements — though the supplements are impressive on their own. They target cellular repair to give you energy in the short term while promoting longevity and activating your body’s repair process. It induces processes that remove “zombie” cells (damaged cells that haven’t died yet) and makes room for new, healthy cell growth.

Customer review | “I have more energy throughout the day and greater mental focus. I also feel a sense of optimism when I think about the possibility of living a long and healthy life.” – Paloma L. (Read more reviews.)


5. Healthgevity

Gluten free
Science backed
Subscriptions available
Vegetarian

Best For | Muscle growth and endurance
Active Ingredients | PeptiStrong®, Senactiv®, AstraGin®
Price Starting At | $75/120 capsules

Healthgevity’s “growth-promoting” ingredients target key aspects of aging to promote longevity. Exercise is one way to support your muscular health, but you can add this Healthgevity supplement as another tool in your kit. As we age, our muscle performance declines. Healthy muscle cells are necessary for mobility. Weakening muscle cells can lead to a weakened immune system, sarcopenia, breathing difficulties, and chronic disease among other concerns. Clinically proven ingredients like PeptiStrong®, Senactiv®, and AstraGin® all improve muscle health and performance at any age. Lower muscle health at younger ages has a direct correlation to chronic disease as you age, so nurturing your muscle health is critical for preservation at any age. This supplement also increases endurance, improves your cellular metabolism, and helps support your immune system, too.


6. Elysium Health

Gluten free
Science backed
Subscriptions available
Vegan

Best For | Plump skin
Active Ingredients | NAD+, Nicotinamide Riboside (NR-E), Pterostilbene (PT)

Price Starting At | $60/60 capsules

Heard the buzz about NAD+? Elysium Health has. Nicotinamide adenine dinucleotide (NAD+) is everywhere these days on the supplement scene — and for good reason. This coenzyme is key for cellular metabolism, making it attractive for longevity supplements. By targeting aging at the source in every cell in your body, it boosts cellular energy and helps you maintain healthy DNA. At any age, NAD+ will give you a spring in your step by instantly boosting energy and fighting fatigue while promoting long-term cellular health. It also boots collagen and ceramides (your skin will thank you) and supports muscle function.

Customer review | “Younger skin: This is truly anecdotal, but I had been taking NMN AND NAD products for almost a year. And then I switched to Basis. But two to three months after taking Basis, I noticed my age-related fragile skin had begun to look and act stronger. It was as if I had de-aged 10 years. I’m sticking with Basis.” – Jonathan C. (Read more reviews.)


7. Brightcore Nutrition

American made
Dairy free
Gluten free
Natural materials
Science backed
Soy free
Subscriptions available

Best For | Heart health
Active Ingredients | MegaNatural® BP Grape Seed Extract, MenaQ7™ Vitamin K2 and MicroActive® CoQ10 
Price Starting At | $90/90 capsules

Looking to target heart health specifically? Brightcore Nutrition can help you lower blood pressure, improve circulation, and target healthy cholesterol levels with a natural blend of antioxidant CoQ10 with grape seed and olive leaf alongside other science-backed ingredients. In the short term, you’ll experience improved endurance while it builds up your overall cardiovascular health. Brightcore says it best: “If laughter is good for your heart, Vitality works like a comedy special with your favorite comedian.” A brand with a sense of humor? Brightcore could be a keeper.

Customer review | “Vitality heart health: Have been taking it for several weeks, and beginning to see some good results. I like the products that don’t have unnecessary ingredients in them.” – Ann T (Read more reviews.)