9 Over-The-Counter Supplements For Urinary Tract Health
The Good Trade editors endorse products we’ve personally researched, tested, and genuinely love. Learn more about our methodology and business model here.
We’ve researched and tested dozens of the best clean supplements — these are our top picks for UTI prevention made with safe, natural ingredients.
UTIs are not only painful and uncomfortable, they also interfere with our ability to live our best lives and be fully present in the moment. And women are 30 times more likely to get a UTI than men. UTIs can be triggered by sex, stress, hormonal changes, travel, exercise — and once you get a UTI, you increase your chances of getting one again. In fact, 26% of women will have an infection return within six months of treatment.
Instead of treating the symptoms after you get a UTI with antibiotics, which can throw off your microbiome and wipe out the good bacteria along with the bad, you can supplement to prevent them and get to the source of the problem. These supplements work to balance your microbiome and work with your body to prevent UTIs before they even happen.
What ingredients should you look for in a UTI-prevention supplement?
It’s important to look for supplements that have active ingredients that are scientifically proven to prevent UTIs and promote urinary tract health. Common ingredients in UTI-prevention supplements include:
Cranberry: Cranberry is a well-known and common ingredient associated with urinary tract health. The active ingredient in cranberries, proanthocyanidins (PAC), prevent bacteria from sticking to the walls of the urethra, which can help prevent UTIs. Many of these supplements use Pancran, a 100% natural blend of whole cranberry ingredients optimized for urinary tract health.
D-Mannose: This is a naturally occurring simple sugar that occurs naturally in the body. It binds to microorganisms in the urine, flushing them out.
Probiotics: Probiotics help balance the vaginal and urinary microbiome using good bacteria. These good bacteria can help protect against pH imbalances in the vagina and bad bacteria in the urinary tract.
Vitamin C: Taking Vitamin C makes the urine more acidic. Bacteria that cause UTIs, like E. coli, often thrive in a neutral or slightly alkaline environment, so creating a more acidic one may prevent UTIs.
Uva Ursi: Also known as the “urinary herb,” this plant offers relief from discomfort by soothing and cooling tissues with allantoin in its leaves. It also contains flavonoids, which are anti-inflammatories, and iridoids, which support a healthy immune response.
Are there natural remedies for clearing up a UTI?
Drinking lots of water and unsweetened cranberry juice, not “holding it,” and peeing after sex are a few ways to naturally help prevent UTIs, but if you already have a UTI it’s best to consult your doctor. These supplements are a great way to prevent further infections, but if it’s progressed to a point of a troublesome UTI already, consult your doctor for the best plan of treatment.
Why are sustainable and clean supplements important?
We prioritize sustainable and clean supplements because they are made with clean ingredients that are third-party tested, responsibly sourced, and free from unnecessary fillers. These products have few ingredients beyond their active ingredients, giving you a pure and high-quality dose, without any extras.
Our criteria:
Our editors have tested, researched, and corresponded with leading supplement brands to pick our favorite formulas for urinary tract health that are clean, science-backed, and easy to take. We regularly update this guide with new favorites that meet the following criteria:
- CLEAN INGREDIENTS | All supplements are free of unnecessary fillers, sweeteners, or artificial additives — and all of them are third-party tested for purity.
- SCIENCE BACKED | These brands use clinical studies or partner with experts to develop evidence-based formulas. We’ve included links here to relevant studies and testimonials.
- EASY TO TAKE | Whether in capsule, powder, or mix-in form, these supplements are easy to incorporate into your daily routine.
Wanting to up your supplement regimen with an eye towards women’s health? Check out our favorite organic women’s multivitamins and PCOS supplements, too.
1. Seed
Best For | Suppository
Active Ingredients | L. crispatus
Prices starting at | $99
Seed creates science-backed probiotics that work holistically for our health and wellness. The brand is the consumer innovation division of Seed Health, a “microbial sciences company pioneering applications of microbes to improve human and planetary health.” What does that mean? They’re creating supplements that are good for us and for the planet. VS-01 is Seed’s clinical research-backed vaginal probiotic suppository. It helps to create an optimal vaginal microbiome, protecting against disruptions in vaginal pH balance. The probiotic/prebiotic supplement has three live strains of L. crispatus, which is the vagina’s most protective bacteria, which addresses the source of pH imbalances, rather than the symptoms. The suppository also includes a prebiotic and nutrient complex for those live strains to thrive. It’s made without preservatives, parabens, artificial fragrances, and dyes, and it’s a non-irritating, non-toxic formula. Seed has a VS-01 starter kit that includes a first-month reset and the second-month maintenance suppositories, and then they offer a subscription after that, where you continue to get the two-suppository maintenance kit.
Customer Review | “I purchased this after a UTI and antibiotic use led to a yeast infection. This has been a life saver restoring balance! I highly recommend as it was quick, effective and got my life back on track!” – Melanie (Read more reviews.)
2. HappyV
Best For | Stick packs
Active Ingredients | Cranberry, D-Mannose, Vitamin C
Prices starting at | $30
HappyV is a wellness brand changing the discussion around women’s health by creating science-backed products to empower healthier living. Their D-Mannose and Cranberry PanCran supplements are formulated with clean ingredients to help support urinary tract health. They have both pills and stick pack options, offering different ways of taking the supplements for your specific needs. Both are formulated with the active ingredients cranberry, which stops bad bacteria from attaching to the urinary tract wall, and D-Mannose, a naturally occurring sugar that traps bad bacteria before flushing it out. They also have Vitamin C, which promotes immune health and helps fight everyday bacterial challenges. HappyV offers a subscribe and save option, and on your third and sixth month, you get a free gift, plus you get free samples, early access to new products, and more. And they give back, too. HappyV partners with Vitamin Angels to provide women and children with the essential vitamins and minerals they need.
Customer Review | “Very easy to take and noticed nearly immediate improvement in symptoms.” – Christie W. (Read more reviews.)
3. Uqora
Best For | Complete urinary tract health system
Active Ingredients | D-Mannose, Potassium Citrate, Vitamin C, Lactobacillus acidophilus & Lacticaseibacillus rhamnosus
Prices starting at | $55
Uqora founder Jenna Ryan understands the pain of frequent UTI’s, so she worked with her partner (who has a background in biochemistry) as well as urologists and physicians, to develop a system to wipe out and prevent UTIs and improve urinary tract health. The Complete Regimen is a three-step bundle that uses science-backed ingredients to help every aspect of your urinary tract health. Part one, Flush, uses D-Mannose, potassium citrate, and Vitamin C to flush your urinary tract system. Part two, Defend, is a daily supplement that offers proactive support for your bladder and urinary tract, cleansing biofilm. It has turmeric root extract, green tea extract, Vitamin D, and D-Mannose. Part three, Promote, supports your vaginal microbiome with Lactobacillus acidophilus & Lacticaseibacillus rhamnosus, probiotics that help balance vaginal pH, and lactoferrin. You can buy the all-in-one bundle, or any of the specific parts of the regimen separately. Uqora also has a subscribe and save option, and they offer a 60-day guarantee, where if it doesn’t give you results you expect, you get your money back.
Customer Review | “I have UTI’s frequently… this is the only product that I’ve tried that takes it away.” – Mari F. (Read more reviews.)
4. Organic Olivia
Best For | Tea blend
Active Ingredients | Cranberry, uva ursi
Prices starting at | $26
Organic Olivia’s Defender Tea is a urinary tract support tea blend that boosts urinary immune health and protects the urinary tract after intimacy. Made with uva ursi, known as the “urinary herb,” and cranberry, the blend supports the bladder and urinary tract. This tea also keeps unwanted bacteria from attaching to the walls of the bladder and urethra, which is helpful in preventing UTIs. And because drinking water is a great way to support the bladder, kidneys, and urinary tract, drinking tea is a great delivery method for bringing these supplements into your system. Defender Tea is third-party tested for pesticides, heavy metals, and microbials to ensure you’re getting the cleanest formula. To brew, you just add one heaping tablespoon to warm water.
Customer Review | “I’ve struggled with UTIs for years and years. Starting this tea has helped so so much and gives me great peace of mind.” – Kate H. (Read more reviews.)
5. O Positiv
Best For | Gummies
Active Ingredients | Cranberry, D-Mannose, Vitamin C
Prices starting at | $27
O Positiv was founded by siblings Brianna and Bobby Britton to redefine women’s health with science-backed products for everything from urinary tract health to menopause. The Uro Urinary Tract Health supplements from O Positiv are made with cranberry, Vitamin C, and D-Mannose to flush the urinary tract and promote health and comfort. They come as daily gummies or capsules, formulated to make peeing comfortable and keep sex, sweat, and stress from getting in the way of that. The supplements use PanCran, which is a clinically formulated blend of whole cranberry ingredients.
Customer Review | “These have been a game changer for me. I have suffered from recurrent utis for years. Once I consistently began taking these I have not gotten a UTI since. That speaks volumes to me.” – Kristi (Read more reviews.)
6. Garden of Life
Best For | Added probiotics
Active Ingredients | Cranberry, 16 probiotic strains, Vitamin D3
Prices starting at | $41
Garden of Life offers supplements with clean, traceable, science-backed, whole food ingredients. The sustainable brand’s urinary tract probiotic is doctor formulated with 16 probiotic strains and 50 billion CFU (colony forming units, a measurement in probiotics). It also has organic Pacran Cranberry and Vitamin D3. All of these work together to promote urinary tract health, as well as digestive and immune support. Garden of Life also gives back! They work with several organizations and causes, including the Special Olympics of Palm Beach County, Women Heart, and the National Parkinson’s Foundation.
Customer Review | “Seems to help tremendously in keeping UTIs at bay.. Do not want to be without.” – Amy W. (Read more reviews.)
7. Pure Encapsulations
Best For | Allergen-free
Active Ingredients | Cranberry, D Mannose
Prices starting at | $57
Pure Encapsulations has over 50 product-specific clinical studies in leading peer-reviewed journals. They’re committed to creating supplements that are pure, focusing on the important ingredients and leaving out the rest. The Cranberry D Mannose supplement from Pure Encapsulations is free from wheat, soy, dairy, eggs, tree nuts, peanuts, sesame, gluten, trans fat, hydrogenated oils, artificial colors, artificial sweeteners, and GMOs. The Daily Supplement is made with 100% cranberry fruit solids and D-Mannose, which promotes urinary tract health and enhances the acidity of urine, which is good for the urinary tract ecology.
8. Solv Wellness
Best For | Concentrated formula
Active Ingredients | Proanthocyanidins (active ingredient in cranberry)
Prices starting at | $37
Solv Wellness creates science backed products to support female pelvic health. GennaMD, their urinary tract health supplement, has a maximum defense formula against UTIs. It’s made with proanthocyanidins (PAC), which is the active ingredient in cranberries. These are the part of cranberries that fights UTI-causing bacteria. The PAC from concentrated cranberry juice extract is 100% soluble, so it works even better to flush the bacteria away. This supplement is backed by three clinical studies, is recommended by urologists, and it’s the highest PAC concentration available in a capsule. The capsule, by the way, is very small, measuring at about 0.5 inches tall.
Customer Review | “I had recurrent UTI’s until starting GennaMD. Now I no longer have to be concerned.” – Debbie H. (Read more reviews.)
9. Now Foods
Best For | Affordability
Active Ingredients | D Mannose
Prices starting at | $17
Now Food’s D Mannose 500mg supplement cleanses the bladder to promote a healthy urinary tract and maintains bladder lining health. This supplement should be taken 1 to 3 times daily with water or unsweetened cranberry juice. Now Foods is a family-owned brand that’s been around for over 50 years. They give back to many organizations, including being a founding partner of Vitamin Angels. Now Foods is also committed to taking care of the planet and making a minimal negative impact on the planet. This includes sourcing sustainable ingredients, using post-consumer recycled plastic for their bottles, having green facilities, and partnering with eco-conscious businesses in their communities.
Customer Review | “As always, fast safe shipping, outstanding product. Highly recommended vendor!” – SuzQ (Read more reviews.)
Featured image is from O Positiv
Brianna Schubert is a Contributing Editor at The Good Trade and the Digital Editor at Milwaukee Magazine. She has a Bachelor of Arts in Journalism from the University of Wisconsin-Milwaukee. Since 2023, Brianna has combined her expertise and investigative skills to deliver thoughtful reviews of sustainable products and home goods, helping readers make informed, eco-conscious choices. Brianna is also the writer behind The Mood Board, a Substack newsletter for creativity and inspiration. When she’s not writing, you can find her cooking up a new recipe, reading and recommending books, cuddling with her cat, or finding hidden gems at vintage and thrift stores. Say hi on Instagram!
